While zinc has been hypothesized to promote wound healing, the research to support daily doses of elemental zinc without a confirmed deficiency is lacking. Some wound care protocols recommend a daily zinc supplement with elemental zinc, such as zinc sulfate or zinc gluconate, to accelerate wound healing. Zinc is also noted to reduce the recovery time of injury and illness. People use oral zinc to help treat colds, but it can decrease the effectiveness of certain drugs and cause side effects. Benefits, deficiency, food sources and side effects. Uses, side effects, interactions, dosage, and warning. Red meats are high in zinc, which can enhance wound healing. Zinc is also important to wound healing and your sense of taste and smell. Zinc orotate has many benefits, including promoting natural wound healing, a strong heart and liver, flexible joints, and healthy bones. The function of zinc throughout the stages of wound healing.
Zinc has a significant function in many cells over the entire process of wound repair. Zinc is a mineral that is found mostly in animal foods. While it is known that zinc deficiency can cause delayed wound healing, the actual role of zinc in wound healing was not known. Diabetes and wound healing diabetes is a condition where the body is not able to use the insulin or there is not enough. Should only be ordered if there is a suspected deficiency. A nutritional formula enriched with arginine, zinc, and antioxidants for the healing of pressure ulcers. It is required for the catalytic activity of approximately 100 enzymes 1,2 and it plays a role in immune function 3,4, protein synthesis, wound healing, dna synthesis 2,4, and cell division. Partial thickness wound repair inflammatory response zinc in wound healing clinical perspectives. Assess need for vitamin mineral supplementation after discharge and develop plan help coordinate ambulatory nutrition followup plan with medical team continue current. Ascorbic acid, zinc and wound healing journal of wound care. An essential trace element for parenteral nutrition. The importance of total parenteral nutritionassociated.
Health service executive, republic of ireland this guideline aims to support all clinicians in the clinical. Zinc also promotes a normal response to inflammation. Epithelialization, angiogenesis, fibroblast proliferation, collagen deposition and crosslinking, wound contraction remodeling 23. Does zinc supplementation accelerate wound healing. Eating well for wound healing alberta health services. A higher incidence of wound complications associated with smoking include prolonged wound healing. Proposed roles of zinc in mg53 mediated wound healing process. The assumption that wounds heal at a constant rate over time, when measured by volume or area, was questioned. Cigarette smoking and its effects on wound healing 29 september 20 journal of wound care, vol. In the treatment of wounds, the role of zinc in wound care still needs to be investigated. Zinc oxide is beneficial in healing incisional wounds in rats,9 and enhances the degradation of wound debris in pig skin. The effects of zinc supplementation on wound healing and. Food sources of zinc include chicken, red meat and fortified breakfast cereals. During the early inflammatory phase of wound healing, zinc levels are markedly increased.
Search strategies included the use of the following medical subject heading mesh terms in pubmed. The main purpose of this study was to investigate the effect of topically applied zinc on leg ulcer healing and examine its effect on some mechanisms in wound healing using standardized animal models. We present here the first comprehensive account of zinc in wound. Zinc is transported through the skin from these formulations, although the systemic effects seem insignificant.
Zinc and vitamin c supplementation in the treatment of. Department of behavioral science, university of kentucky college of medicine, lexington. It is required for the catalytic activity of approximately 100 enzymes 1, 2 and it plays a role in immune function 3, 4, protein. Zinc supplement oral route, parenteral route description. Journal of surgical research 27, 168174 1979 zinc sulfate and wound healing john v. The present study was undertaken to evaluate of nigella sativa oil nso and zincsilver cream in a rat model of wound healing by means of clinical appearance, histopathology, oxidative stress parameters. Significant wound healing was observed for chitosanpvazno after 7 days compared to chitosan, chitosanpva, and phosphatebuffered saline pbs samples.
We investigated the effect of localiy applied zinc on the healing of partial thickness skin wounds in the do mestic pig using two zinc compounds zinc oxide and. Mg53 exists as intrinsic intracellular vesicles which could be secreted into blood circulation as a myokine to mediate wound healing. The effect of zinc on postneurosurgical wound healing. The role zinc plays in wound healing can be viewed from two perspectives. In general, any vitamins and nutrients you put into your body will aid in the recovery. Several published studies have clearly illustrated that zinc is a vital micronutrient for postneurosurgical wound healing. It is well known that zinc zn, an essential trace element, plays a role in wound healing. With a varied diet, your body usually gets enough zinc. Zinc in wound healing modulation pubmed central pmc. The harmful effects of cigarette smoking on wound healing have been reported in multiple studies. In the treatment of wounds, the role of zinc in the wound healing process has been highly debated.
Zinc is a nutrient that plays many vital roles in your body. Zinc is involved in numerous aspects of cellular metabolism. Wound healing is an intricate and dynamic process which can be subdivided into a series of phases including. Pdf comparison of the effects of zincsilver cream and. A number of these supplements contain arginine, glutamine, ascorbic acid, protein, and other micronutrients, in addition to zinc, and have had variable impacts on wound healing. Immune system and wound healing the bodys immune system needs zinc to do its job. Normal wound healing vitamin a 35 days postinjury x 23 weeks. Although the importance of zn supplementation in total parenteral nutrition tpn has been.
Zinc confers resistance to epithelial apoptosis through cytoprotection against reactive oxygen species and bacterial toxins possibly through antioxidant activity of. Zinc is an essential trace element for human nutrition that is an integral part of many enzyme systems, including dna polymerase complex. Older people and children in developing countries who have low levels of zinc might have a higher risk. The potential role of zinc supplementation on pressure. Lack of zinc may lead to poor night vision and woundhealing, a decrease in sense of taste and smell, a. Pdf topical zinc is widely used in wound treatment although the beneficial effect of zinc has only been documented in zincdeficient patients who were. Deficiency is associated with delayed wound healing commonly seen in patients with diarrhea, malabsorption or hypermetabolic stress in sepsis, burns, or serious injury poor zinc status can adversely affect b and t lymphocyte production, leading to delayed wound healing.
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